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RESEARCH ON, IDENTIFICATION OF AND SCREENING FOR BIOLOGICAL MATERIALS USING LOW ENERGY ELECTRON MICROSCOPY

机译:低能电子显微镜对生物材料的研究,鉴定和筛选

摘要

Described herein is a system and method for conducting research on and/or screening for viruses, capsids, antibodies, prions, proteins and DNA using a low energy electron microscope (LEEM). In some implementations, the system takes images of a biological sample, extracts information (e.g., size or shape of contents) from the taken images, and determines the presence or absence of biological agents, such as viruses, capsids, antibodies, prions, proteins and DNA, based on the extracted information. In some implementations, the system observes, identifies, and/or detects interactions between antibodies and viruses or other microbes, capsids, antibodies, prions, proteins and DNA, such as the binding of the antibodies to its cognate ligand. In some implementations, the system screens biological samples, based on detected interactions with known antibodies, to determine whether a person should be granted access to a controlled, restricted or protected location.
机译:本文描述了一种用于使用低能电子显微镜(LEEM)对病毒,衣壳,抗体,病毒,蛋白质和DNA进行研究和/或筛选的系统和方法。在一些实施方式中,系统拍摄生物样品的图像,从所拍摄的图像中提取信息(例如,内容物的大小或形状),并确定是否存在生物制剂,例如病毒,衣壳,抗体,病毒,蛋白质和DNA,基于提取的信息。在一些实施方式中,系统观察,识别和/或检测抗体与病毒或其他微生物,衣壳,抗体,病毒,蛋白质和DNA之间的相互作用,例如抗体与其同源配体的结合。在一些实施方式中,系统基于检测到的与已知抗体的相互作用来筛选生物样品,以确定是否应准许人进入受控,受限或受保护的位置。

著录项

  • 公开/公告号WO2013138208A1

    专利类型

  • 公开/公告日2013-09-19

    原文格式PDF

  • 申请/专利权人 DENNIS ROBERT T.;BEYERS JOSEPH W.;

    申请/专利号WO2013US30093

  • 发明设计人 DENNIS ROBERT T.;BEYERS JOSEPH W.;

    申请日2013-03-10

  • 分类号G01N23/04;G01N33/543;G06F19;

  • 国家 WO

  • 入库时间 2022-08-21 16:30:41

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