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CARTILAGE-SPECIFIC HIF-2 TRANSGENIC MOUSE AS AN ANIMAL MODEL FOR ARTHRITIS, AND USE THEREOF
CARTILAGE-SPECIFIC HIF-2 TRANSGENIC MOUSE AS AN ANIMAL MODEL FOR ARTHRITIS, AND USE THEREOF
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机译:特定于关节炎的HIF-2转基因小鼠作为关节炎的动物模型及其用途
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摘要
The present invention relates to a transgenic fertilized egg in which expression constructs, excluding human expression constructs, are introduced, including: (a) a nucleotide sequence encoding hypoxia-inducible factor 2α (HIF-2 α); and (b) a transcription-regulating sequence which is operatively linked to the nucleotide sequence, as well as to a transgenic animal model for arthritis obtained therefrom. A transgenic mouse transformed with a recombinant expression vector of the present invention may be very useful as a therapeutic model for arthritis, which may be used in studies on the cartilage degeneration process. In addition, the transgenic mouse of the present invention may be applied to a method for screening arthritis therapeutics.
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