Combination therapy of irradiation and MSC-TRAIL for the treatment of glioma

摘要

PURPOSE: A method for treating a glioma by combining radiation and TRAIL-expressing mesenchymal stem cells is provided to induce tumor apoptosis. CONSTITUTION: A composition for treating a glioma, which is combined with radiation therapy, contains mesenchymal stem cells(MSCs) which secretes a tumor necrosis factor-related apoptosis-inducing ligand(TRAIL). The MSCs are human umbilical cord blood-derived MSCs. A method for treating a glioma for mammals exclusive of humans comprises: a step of irradiating the mammal with radiation; and a step of administering the composition to mammal.