Composition for periodontal regeneration comprising fibrin and fibrinolysis inhibitor

摘要

PURPOSE: A composition for gingiva regeneration including fibrin and fibrinolysis inhibitor is provided to promote differentiation of cementoblasts and to regenerate the gingival of cementum and alve olar bone. CONSTITUTION: A composition for gingiva regeneration includes fibrin and fibrinolysis inhibitor as active ingredient. The fibrinolysis inhibitor is aminocaproic acid. The composition additionally includes chitosan as the sustained-release carrier of the aminocaproic acid. 5-20 wt% of the fibrinolysis inhibitor and fibrin are included. The fibrin and fibrinolysis inhibitor suppress the cell apoptosis of the cementoblast and promotes the regeneration of the gingiva. The fibrin and fibrinolysis inhibitor has an activity which promotes the gene expression related to the differentiation of ALP(alkaline phosphatase) cementoblasts, Runx 2(runt-related transcription factor 2), type I-form collagen, OCN(osteocalcin), or BSP(bone sialoprotein). An injection type recycled material for gingival regeneration is provided by mixing aminocaproic acid with the fibrin substrate.