MICROCAPSULES WITH HYDROPHOBIC DRUG-LOADED SOLID LIPID CORE SURROUNDED BY PROTEIN-POLYSACCHARIDE HYBRID MEMBRANE CROSS-LINKED WITH TANNIC ACID

摘要

PURPOSE: A drug delivery system which is covered with a tannic acid-crosslinked protein-polysaccharide hydrid membrane is provided to enable continuous drug release to maintain a drug effect. CONSTITUTION: A drug delivery is covered with a tannic acid-crosslinked protein-polysaccharide hybrid membrane. The protein is positively-charged gelatin in a pH of 3.0-5.0. The gelatin is fish gelatin, bovine gelatin, or procine gelatin. The protein is also a positively-charged milk protein in a pH of 3.0-5.0. The milk protein is casein or whey protein. The polysaccharides are gum arabic mucopolysaccharide, alginic acid, pectin acid, or hyaluronic acid.