A MICRONIZED PARTICLE PROCESS OF CERAMIDE USING SUPERCRITICAL FLUID AND IT'S APPLICATION

摘要

PURPOSE: A manufacturing method of ceramide microparticles is provided to be able to provide minute ceramide particles with an increased skin absorption rate by modification of temperature and pressure which are operating variables in the supercritical fluid process, or flux variation of a solution of ceramide and an organicl solvent, and the supercritical carbon dioxide. CONSTITUTION: A manufacturing method of ceramide microparticles using the supercritical fluid process comprises a step of forming ceramide particles by contacting a mixture solvent in which ceramide is dissolved in an organic solvent to supercritical fluid with spraying; and a step of removing the organic solvent which has been used in the mixture solution by introducing the supercritical fluid to the ceramide particles. Ceramide is used at a weight fraction of 0.0001-0.50 to the weight fraction of the organic solvent.