PROLIFERATION OF BONE MARROW-DERIVED IMMUNE REGULATORY CELLS AND IMMUNE REGULATORY B LYMPHOCYTES IN VIVO AND IN VITRO BY ACTIVATING GPCR19 PATHWAY

摘要

PURPOSE: Proliferation of bone marrow-derived immune regulatory cells and immune regulatory B lymphocytes in vivo and in vitro is provided to show a method for screening a therapeutic agent for treating GPCR19-related diseases or a method for analyzing efficacy of a GPCR19 agonist, thereby producing an anti-inflammatory pharmaceutical composition.;CONSTITUTION: An immune regulatory B cell is transformed or amplified by treatment with toll-like receptor (TLR) signal transduction inducing factor and a GPCR19 agonist or with myeloid-derived suppressor cells (MDSC). The immune regulatory B cells show CD23^hi phenotype on the surface and have an anti-inflammatory activity. The immune regulatory B cells express CD21 and CD23. The TLR signal transduction inducing factor is a factor derived from bacteria, fungi, virus, allergen, or cancer cells, or a self-derived factor. The GPCR19 agonist is a compound of chemical formula 1 or a salt or a hydrate thereof.;COPYRIGHT KIPO 2013