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Colon specific Celecoxib prodrug compound and pharmaceutical composition for treating or preventing colonic disease comprising the same
Colon specific Celecoxib prodrug compound and pharmaceutical composition for treating or preventing colonic disease comprising the same
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机译:结肠特异性塞来昔布前药化合物和用于治疗或预防结肠疾病的药物组合物
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摘要
The present invention relates to a celecoxib precursor compound and to a pharmaceutical composition containing the compound as an active ingredient for treating or preventing colonic diseases. More particularly, the present invention relates to a celecoxib precursor compound and to a pharmaceutical composition containing the compound as an active ingredient for treating or preventing colonic diseases, wherein the celecoxib precursor compound is not absorbed and stays in a stable state in a stomach and small intestine but metabolized in the colon by means of an enzyme so as to exhibit medicinal effects, thus enabling the utilization of celecoxib, which is a COX-2 inhibitor, in treating or preventing colonic diseases.
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