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Solid preparation for oral administration comprising choline alfoscerate or pharmaceutically acceptable salt thereof and method for manufacturing the same
Solid preparation for oral administration comprising choline alfoscerate or pharmaceutically acceptable salt thereof and method for manufacturing the same
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机译:用于口服的固体制剂,其包含阿魏酸胆碱或其药学上可接受的盐及其制备方法
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摘要
PURPOSE: An oral solid formulation containing choline alfoscerate and a method for manufacturing the same are provided to improve stability to moisture, temperature, and light and to enable long-term storage. CONSTITUTION: A pharmaceutical composition comprises: a drug part containing choline alfoscerate or a pharmaceutically acceptable salt thereof; a coating part which is formed at the outside of the drug part and contains a water soluble polymer; and pharmaceutically acceptable additives. The choline alfoscerate is L-alpha-glyceryl phosphoryl choline. An oral solid formulation contains the pharmaceutical composition. The solid formulation is a tablet, a capsule, granules, or a pellet. A method for preparing the pharmaceutical composition comprises: a step of spraying a coating solution containing the water soluble polymers and preparing a drug particle; and a step of adding and mixing the pharmaceutically acceptable additives to the drug particle.
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