The present invention includes the steps of selecting factors affecting exacerbation of asthma among daily weather and air pollution factors on a computer; Modeling using conditional logistic regression; And it provides a method for predicting the risk of weather and air pollution factors for diagnosing the exacerbation of severe asthma, comprising the step of quantitative analysis using a case-crossover method. The present invention makes it possible to determine meteorological and air pollution factors that affect the exacerbation of severe asthma, and to predict the risk thereof, and thus is useful for the diagnosis and prevention of severe asthma exacerbations.
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