METHOD FOR EARLY DIAGNOSIS AND ESTIMATION OF PATHOPHYSIOLOGY OF PREECLAMPSIA

摘要

invention preeclamptic that proteins expressed specifically during the screening methods and early diagnosis and prediction of pre-eclampsia relates to a marker for. By the screening method of the placenta-specific protein expressed during preeclampsia according to the use of a two-dimensional electrophoretic analysis of the present invention, ) separating the protein from the placenta, placental tissue, ) the separated proteins to a two-dimensional electric step of two-dimensionally through the electrophoretic separation, and ) comprises the step of comparing and analyzing normal placenta protein or protein preeclamptic placenta through the scanning and the image difference between the gel and the separated proteins, scan the images and a difference between the gel Comparative analysis of the protein through the placenta, the placenta is characterized in that the two screening proteins showing a difference of at least 140%. Further, according to the invention, the marker for the early diagnosis and prediction of preeclampsia, Chaperone (chaperonin), ER-60 Pro-thiazol claim (ER-60 protease), di-iso-citrate dehydrogenase 1 (Isocitrate dehydrogenase 1 ), aldehyde reductase 1 (Aldehyde reductase), the human dose al reductase (human Aldose reductase) in combination with the blood Lestat (Fidaresta) Chain B, voltage-dependent anion channel 1 (Voltage-depentant anion channel 1), the nuclear chloride channel (Nuclear chloride channel), car depsin D (Cathepsin D) chain H, Mu Force as glycolic three rate matriptase 1 (Phosphoglycerate mutase 1), endoplasmic reticulum protein (Endoplasmic reticulum protein), PSMA2 (proteasome_alpha_type_2) protein, glutathione S-transferase-ray Article (Glutathione S-transferase), Ig heavy chain v region (Ig heavy chain v region), smooth muscle myosin alkali light chain (Smooth muscle myosin alkali light chain) and fatty acid binding protein (Fatty acid binding protein) from a group consisting of proteins is selected. ;