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Drug-eluting stent using block copolymers composed of poly(hydroxyoctanoate) and biodegradable polymer
Drug-eluting stent using block copolymers composed of poly(hydroxyoctanoate) and biodegradable polymer
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机译:使用由聚羟基辛酸酯和可生物降解的聚合物组成的嵌段共聚物的药物洗脱支架
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摘要
PURPOSE: A non-vascular drug-eluting stent using a drug carrier is provided to regulate local drug elution and to prevent restenosis. CONSTITUTION: A drug carrier by block copolymer synthesis of polyhydroxyoctanoate and biodegradable polymers is prepared by supporting hydrophobic drugs in a block copolymers formed by block copolymerization of poly(3-hydroxyoctanoate)(PHO) into biodegradable polyester or polyester polymers. The polymer is poly(DL-lactide-co-glyucolide)(PLGA). The hydrophobic drug is paclitaxel. A non-vascular drug-eluting stent is prepared by coating the surface of the stent with the polymer drug carrier.
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