Methods for Screening Therapeutics for X-linked Adrenoleukodystrophy and Autologous Differentiated Oligodendrocytes Therefor

摘要

The invention Station in inducing differentiation and de-differentiation induced pluripotent stem cell method for producing a pluripotent stem cell relates to the X- associated Adrenoleukodystrophy disease screening method using a cell . The present invention can be produced X- associated Adrenoleukodystrophy (X-linked adrenoleukodystrophy, X-ALD) de-differentiation induced pluripotent stem cells from human fibroblasts derived from a patient . May also be used to reverse the diluent projection differentiated glial differentiation-inducing pluripotent stem cells to determine the efficacy of a drug through the screening method of the X- associated Adrenoleukodystrophy therapeutic candidates . In particular, de-differentiation induced pluripotent stem cells can self (autologous) by making a rare glial turning the advantage of patient-specific treatment is available through the production process . ;