COMPOSITIONS AND METHODS OF FACILITATING HYPOSALIVATION AND MAINTENANCE OF COMFORT FEELING IN THE ORAL CAVITY

摘要

1. A method of at least increasing oral moisturization and relieving hyposalivation-related symptoms, comprising: preparing a topical composition for oral administration, which comprises, as a salivating agent, a combination of grape seed extract and citrus fruit extract, the combination being effective as stimulating salivation and is present in a concentration effective to relieve the symptom or to increase the hydration of the oral cavity; teaching test results, which indicate that the extract of grape seed extract and citrus fruits provides relief from a symptom or increase oral moistening; and the presentation of the composition along with the test result. 2. The method according to claim 1, wherein the hyposalivation-related symptom is selected from the group consisting of: dry mouth, bad breath, thick saliva, altered taste and difficulty in speaking or swallowing. The method according to claim 1, wherein the topical composition is selected from the group consisting of chewing gum, a soluble strip, a tablet, a troche, a mouthwash, a spray, a toothpaste, an ointment, a foam, a salivary booster, and a powder that is optionally impregnated with a carrier .4. The method according to claim 1, wherein the grape seed extract and citrus fruit extract are present in synergistic amounts. The method according to claim 1, wherein the grape seed extract and citrus fruit extract are present in a concentration equal to or less than 1 wt.% Of the topical composition. The method according to claim 1, in which to