POLYEPEPTIDES SELECTIVE WITH RESPECT TO INTEGRINE ανβ CONJUGATED WITH THE VERSION OF HUMAN SERUM ALBUMINE (HSA), AND THEIR PHARMACEUTICAL APPLICATIONS

摘要

1. A polypeptide containing the amino acid sequence of SEQ ID NO: 1, where the polypeptide is conjugated to a variant of human serum albumin (HSA) containing the amino acid sequence of SEQ ID NO: 4, or a pharmaceutically acceptable salt of the polypeptide. A polypeptide containing the amino acid sequence of SEQ ID NO: 1, where the polypeptide is conjugated to a variant of human serum albumin (HSA) containing the amino acid sequence of SEQ ID NO: 6, or a pharmaceutically acceptable salt of the polypeptide. 3. The polypeptide according to claim 1 or 2, where the specified polypeptide contains a linker amino acid sequence. The polypeptide of claim 3, wherein said linker amino acid sequence comprises a combination of glycine and serine amino acids. The polypeptide according to claim 3, where the specified linker amino acid sequence contains the amino acid sequence of SEQ ID NO: 8.6. A polypeptide containing the amino acid sequence of SEQ ID NO: 9, or a pharmaceutically acceptable salt of said polypeptide. 7. A polypeptide comprising the amino acid sequence of SEQ ID NO: 11, or a pharmaceutically acceptable salt of said polypeptide. 8. A polypeptide encoded by a polynucleotide containing the nucleotide sequence of SEQ ID NO: 10.9. A polypeptide encoded by a polynucleotide containing the nucleotide sequence of SEQ ID NO: 12.10. A physiologically acceptable composition comprising a polypeptide according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. A physiologically acceptable composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 9, or