ANTIVIRAL MEDICATION BASED ON NEMATOPHAGOUS FUNGUS Duddingtonia flagrans

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: anti-viral preparation represents water extract from strain of namatophagous fungus Duddingtonia flagrans F-882, obtained by extraction of fungus biomass with ratio biomass:water 1:5, with further removal of insoluble deposit. Preparation possesses high activity against human immunodeficiency virus of the first type, viruses of human and avian influenza of type A and pox vaccine virus. Index of neutralisation of human influenza A virus in culture of MDCK cells constitutes 3.5 lg, of avian influenza A - 2.5-3.0 lg. Virus-neutralising preparation action with respect to pox vaccine virus no Vero cells constitutes 25-50% of cells. If preparation in concentration 25 mcg/ml is introduced into MT-4 cells simultaneously with virus adsorption inhibition of HIV-1reproduction, or in concentration 12.5 mcg/ml after adsorption in cells constitutes 100%.;EFFECT: increase of activity.;2 cl, 6 tbl, 5 ex