METHOD OF PRODUCING 1,5-BIS(2-HYDROXYPHENOXY)-3-OXAPENTANE MONOHYDRATE

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a method of producing 1,5-bis(2-hydroxyphenoxy)-3-oxapentane monohydrate, which is an intermediate product during synthesis of crown ethers which have complexing and solvating properties and are widely used in different fields of chemistry, engineering, biology and medicine. The method involves reaction of β,β'-dichloroethyl ether with pyrocatechol, the reaction being carried out using an excess amount of pyrocatechol in a medium of glycerol and in the presence of sodium carbonate, as well as in the current of an inert gas, at high temperature and while stirring, followed by separation of the end product. The starting pyrocatechol, which is taken in 6-10% stoichiometric excess, is first treated with sodium carbonate in glycerol medium with intense stirring and at temperature of 60-80°C, after which the formed solution is heated to 145-150°C and β,β'-dichloroethyl ether is added, stirred at the same temperature, cooled and the end product is deposited from the reaction solution using ice water and the filter cake is washed with water to neutral reaction.;EFFECT: disclosed method enables to obtain the end product with high output.;4 cl, 2 ex