OXYNTOMODULIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, METHOD OF TREATING AND PREVENTING OBESITY AND COMORBIDITIES (VERSIONS) AND MEDICINE (VERSIONS)

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: compounds of the present invention are novel peptide analogues of oxyntomodulin (oxm) wherein one or more amino acid residue of the sequence oxm are replaced. The replacement of amino acid residues 15-24 of the peptide oxm either by amino acid residues 968-977 of the α-latroxin peptide (and versions thereof), or by amino acid residues 15-24 of extendin-4 (and versions thereof), or combining the amino acid residues of these sources, and/or the replacement of amino acid residues 27-33 of the peptide oxm by amino acid residues 27-33 of extendin-4, and/or adding the amino acid residues to an C-terminal of the peptide, enables producing a number of the analogues oxm presenting oxm-like activity to reduce food consumption, and according to some other aspects, more evident ability to reduce food consumption.;EFFECT: reduced food consumption.;32 cl, 779 dwg, 106 ex