STRAIN OF FLU VIRUS A/IIV-Anadyr/177-ma/2009 (H1N1) pdm09, ADAPTED TO TISSUES OF LIGHT LABORATORY RODENTS

摘要

FIELD: biotechnologies.;SUBSTANCE: strain of a flu virus A/IIV-Anadyr/177-ma/2009 (H1N1) pdm09 is proposed, which is adapted to tissues of light laboratory rodents. The strain is produced by means of multiple passage of a parent strain A/IIV-Anadyr/177/2009 (H1N1) on models of developing hen embryos, infected into the allantoic cavity, and pedigreeless laboratory white mice infected intranasally. The strain may be actively reproduced in tissues of light laboratory rodents, casing lethal pneumonia in them. The strain is deposited into the state collection of viruses of the Scientific and Research Institute of Virology named after D. I. Ivanovskiy under the No.2721.;EFFECT: strain may be used to study efficiency of antivirus chemical preparations, means and methods for flu treatment and related pneumonias, on the model of experimental pneumonia of laboratory rodents.