PEPTIDE POSSESSING ANTIATHEROSCLEROTIC ACTION AND COMPOSITION FOR PREVENTING AND TREATING ATHEROSCLEROTIC VASCULAR DISEASE

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to immunology and medicine, namely to new peptides of general formula: X-CC-C(Y)-CC-Z, wherein X is a B-cell epitope of apolipoprotein B100 protein; C is an amino acid residue specified in K or R; Y is an immunoadjuvant specified in a group of Pam₁CSS-; Pam₂CSS-, Pam₃CSS-; Z - T-helper epitope specified in AKFVAAWTLKAAA, KLIPNASLIENCTKAEL, QYIKANSKFIGITE.;EFFECT: peptide preparations possess higher antisclerotic activity as compared to their analogues, and the compositions thereof are of practical interest as a vaccine for preventing and treating atherosclerotic vascular disease.;9 cl, 1 dwg, 6 tbl, 7 ex