Use of substituted dicyclohexylmethanol derivatives as antimicrobial active substance and anti-acne-, antidandruff-, deodorant- or antiperspirant active substance, and in cosmetic- or pharmaceutical formulations and medical devices

摘要

Use of substituted dicyclohexylmethanol derivatives (I) as an antimicrobial active substance, is claimed. Use of substituted dicyclohexylmethanol derivatives of formula (I) as an antimicrobial active substance and an anti-acne-, antidandruff-, deodorant- or antiperspirant active substance, is claimed. R1-R10 : H, OH, OCOCH 3, CH 2OH, SO 3H, halo, 1-20C alkyl or 1-20C alkoxy. Provided that at least one of the groups R1-R10 is OH or alkoxy group having 1-20 carbon atoms. Independent claims are also included for: (1) a formulation comprising (I) and at least one carrier; (2) preparing the formulation, comprising mixing (I) with the carrier; (3) (I); and (4) preparing (I). [Image] ACTIVITY : Antimicrobial; Antiseborrheic; Dermatological. The antibacterial activity of (I) was tested against Staphylococcus epidermidis (strain ATCC 12228). The results showed that 4-(cyclohexyl-hydroxy-methyl)-cyclohexanol (2% in water-(12%) ethanol mixture) decreased colony forming units from 1.6x 10 4 to 7.4x 10 3. MECHANISM OF ACTION : None given.