PROCESSES FOR PREPARING N-HETEROARYL-N-ARYL-AMINE BY REACTING N-ARYL CARBAMIC ACID ESTER WITH HALO-HETEROARYL, AND ANALOGOUS PROCESSES

摘要

PROBLEM TO BE SOLVED: To provide processes for producing diaryl amine compounds or salts thereof.SOLUTION: The present invention relates to processes for producing diaryl amine compounds of the formula (I) or salts thereof. The processes comprise coupling a compound of the formula (II) with an amine of the formula (III) in the presence of a transition metal catalyst or an alkali metal salt. Ar1 and Ar2 are independently Q; each Q is an aryl or heteroaryl ring system optionally fused to a saturated or unsaturated 5-8 membered ring having 0-4 heteroatoms; and Q is optionally substituted as defined in the claim 1. X is a leaving group; Y is -C(O)-O-Z; and Z is selected from C-Caliphatic, benzyl, Fmoc, -SOR' and Q, provided that Q is not substituted with X or alkyne; where R' is as defined in the claim 1.