IDENTIFICATION OF MICRORNA THAT ACTIVATES EXPRESSION OF BETA MYOSIN HEAVY CHAIN

摘要

PROBLEM TO BE SOLVED: To provide a method comprising the step of identifying miR-208, which is a microRNA inducing expression of -myosin heavy chain (-MHC) and repressing fast skeletal muscle contractile protein genes.SOLUTION: Inhibition of this function is proposed as treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.