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Identification of microRNAs that activate beta myosin heavy chain expression
Identification of microRNAs that activate beta myosin heavy chain expression
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机译:鉴定激活β肌球蛋白重链表达的microRNA
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摘要
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of ²-myosin heavy chain (²-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
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