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Targeted microRNA for treating liver cancer

机译:靶向微小RNA治疗肝癌

摘要

Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
机译:本文提供了治疗肝癌的方法。这些方法包括给予包含修饰的寡核苷酸的化合物,其中修饰的寡核苷酸靶向miRNA。本文还提供了用于治疗肝癌的组合物。这样的组合物包括包含修饰的寡核苷酸的化合物,其中所述修饰的寡核苷酸靶向miRNA。已经确定某些miRNA在肝癌,例如肝细胞癌中过表达,因此被选择用于经修饰的寡核苷酸靶向。此外,已经确定某些miRNA在暴露于二恶英的肝癌细胞中过表达,因此被选择用于修饰寡核苷酸的靶向。已经发现对这些miRNA中的某些的反义抑制可抑制细胞增殖并诱导凋亡。

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