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Covalent binding of ligands to nucleophilic proteins induced by non-covalent bonds
Covalent binding of ligands to nucleophilic proteins induced by non-covalent bonds
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机译:非共价键诱导配体与亲核蛋白的共价结合
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摘要
A covalently reactive ligand analogue (CAL) of formula (1): wherein, L1 . . . Lx . . . Lm are components defining a ligand determinant, Lx is a component unit of the ligand determinant selected from the group consisting of an amino acid residue, sugar residue, a fatty acid residue and a nucleotide, L is a functional group of Lx, Y is atom, covalent bond or linker, Y is an optional charged or neutral group Y is a covalently reactive electrophilic group that reacts specifically with a receptor that binds to said ligand determinant, and n is an integer from 1 to 1000 m is an integer from 1 to 30.
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机译:式(1)的共价反应性配体类似物(CAL):其中,L 1。 。 。 x 。 。 Lm是定义配体决定簇的组分,Lx是选自氨基酸残基,糖残基,脂肪酸残基和核苷酸的配体决定簇的组分单元,L是Lx的官能团,Y是原子,是共价键或接头,Y是任选的带电或中性基团Y是与与所述配体决定簇结合的受体特异性反应的共价反应性亲电子基团,n是1至1000 m的整数是1至1的整数30岁
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