7,2 '-dehydrated puerarin and its salt derivatives, preparation method and application thereof

摘要

7,2''-Dehydrated puerarin of formula (I) and its salts derivatives are disclosed in the present invention. 7,2''-Dehydrated puerarin of the present invention is obtained by the intramolecular Mitsunobu reaction of puerarin, and can significantly shorten the duration of arrhythmia and significantly prolong the clotting-time. The monomer compound and its pharmaceutically acceptable salts can be formulated into oral preparation or injection for treating cardiovascular and cerebrovascular diseases such as arrhythmia, coronary heart diseases, angina, myocardial infarction and cerebral infarction etc.