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It becomes the main component of individual conversion remedy vaccination of the patient, the tumor-related antigen of the tumor patient (TAA) being the manner which identifies the choice target antigen
It becomes the main component of individual conversion remedy vaccination of the patient, the tumor-related antigen of the tumor patient (TAA) being the manner which identifies the choice target antigen
Identifying the preferential target antigens of antitumor T cells comprises isolating T cells from the blood of a tumor patient, transfecting autologous dendritic or B cells with a selection of mRNAs coding for tumor-associated antigens, contacting the T cells with the dendritic or B cells, and identifying the antigens recognized by the T cells. Independent claims are also included for: (1) identifying a tumor in a patient on the basis of an antigen expression pattern determined as above; (2) producing an individualized antitumor vaccine by identifying tumor-associated antigens as above and formulating the antigens as a vaccine; (3) treating a tumor disease on the basis of an antigen expression pattern determined as above. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : Vaccine.
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