Is a main component of the individualized therapeutic vaccination of the patient, detection of T cell response patterns of the individual against tumor-associated antigens (TAA) of the tumor patients

摘要

Identifying the preferential target antigens of antitumor T cells comprises isolating T cells from the blood of a tumor patient, transfecting autologous dendritic or B cells with a selection of mRNAs coding for tumor-associated antigens, contacting the T cells with the dendritic or B cells, and identifying the antigens recognized by the T cells. Independent claims are also included for: (1) identifying a tumor in a patient on the basis of an antigen expression pattern determined as above; (2) producing an individualized antitumor vaccine by identifying tumor-associated antigens as above and formulating the antigens as a vaccine; (3) treating a tumor disease on the basis of an antigen expression pattern determined as above. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : Vaccine.