Avian antibodies that specifically bind to human HMGB1, immunoassay reagents for immunological assay methods and human HMGB1 human HMGB1

摘要

The object of the present invention, is to provide a high probability, the antibody anti-human HMGB1 binding capacity of human high mobility group box protein-1 and (HMGB1) is high. The present invention is to provide an immunoassay reagent and an immunoassay with high sensitivity of human HMGB1 in the sample using an anti-human HMGB1 antibodies such. Specifically, the following expression of human HMGB1 (I): specifically binds to the amino acid sequence represented by Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys Ala Glu Lys Ser (I), a bird-derived anti-human HMGB1 wherein the use of the antibody and antibody, immunoassay reagents and immunoassay of human HMGB1 in a sample is provided.