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COMPOSITIONS, SYSTEMS AND METHODS BASED ON THE DIFFERENTIATION OF EPICARDIAL CELLS TO TYPICAL AND ATYPICAL FATES
COMPOSITIONS, SYSTEMS AND METHODS BASED ON THE DIFFERENTIATION OF EPICARDIAL CELLS TO TYPICAL AND ATYPICAL FATES
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机译:基于微细胞分化为典型命运和非典型命运的组合物,系统和方法
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摘要
Disclosed are epicardium-derived mesenchymal cells (EPDCs) that differentiate to fates that are commonly adopted by mesenchymal cells elsewhere in the body, but not currently associated with the epicardium. Also disclosed are methods, systems and assays relating to adipocyte and/or osteogenic differentiation in EPDCs that are often related to disease or disregulated states, i.e. the “atypical” fates of epicardium-derived cells. Disclosed are specific EPDC cells that model both the typical fates and atypical fates of EPDCs, and resultant uses of such EPDC cells in systems, methods, compositions and drug discovery.
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