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Identification Of Novel Cell Surface Markers For Pancreatic Progenitor Cells And Definite Endodermal Cells
Identification Of Novel Cell Surface Markers For Pancreatic Progenitor Cells And Definite Endodermal Cells
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机译:胰腺祖细胞和确定的内胚层细胞的新型细胞表面标志物的鉴定
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摘要
Methods of identifying, isolating and qualifying pancreatic progenitor cells and definite endodermal cells. An isolated population of pancreatic progenitor cells, including at least 75% of cells having a TROP-2+ and/or TROP-2+/GPR50+ expression pattern and an isolated population of definite endodermal cells, including at least 50% of cells having a;SOX17+/SOX7+/GSC+/CER+/FOXA2+/CXCR4+/NANOG expression pattern. Nucleic acid constructs including a reporter protein under the transcriptional regulation of SOX17 regulatory sequence or of PDX1 regulatory sequence, and cells comprising same, and methods and kits using same.
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