Metal complexes of thiourea and derivatives as metal delivering anti-cancer and anti-inflammatory agents

摘要

The present invention relates to metal thiourea complexes comprising N-substituted thiourea ligands and sulfur-coordinated metal ions, and methods for using the metal thiourea complexes for delivering otherwise unstable or impermeable metal ions to mammalian cells, for inhibiting cancer cell growth and inflammation, and for inhibiting the activities of associated drug targets under in vitro and in vivo conditions. The metal complexes of N-substituted thiourea are defined by the following formula (Ia or Ib) wherein R₁ can be H, alkyl, alkenyl, alkynyl, aryl or heterocyclic groups; R₂ can be H, alkyl, alkenyl, alkynyl or aryl groups; n=1 to 4; X⁻ is a pharmaceutically acceptable anion (chloride, bromide, iodide, hexafluorophosphate, or triflate) and M is a coinage metal (Au, Ag, or Cu).;