Methods and Compositions for Maintaining Blood-Brain Barrier Integrity

摘要

Methods of maintaining or improving blood-brain barrier integrity and increasing resistance to cytokine-induced cell permeability are disclosed. It has been discovered that down-regulating the expression or production of sulfoglucuronyl glycolipids, for example SGPG, in endothelial cells of the blood-brain barrier or the blood-nerve barrier reduces apoptosis of these endothelial cells and thereby promotes the integrity of the barriers. Promoting the integrity of these barriers includes, but is not limited to reducing or inhibiting passage of immune cells, pathogenic immunoglobins, or bio-degrading molecules across the blood-brain barrier or blood-nerve barrier into the nervous system. Down-regulating expression or production or SGPG also increases the resistance of the endothelial cells to cytokine-induced cell permeability.