ULTRASENSITIVE, SUPERFAST, AND MICROLITER-VOLUME DIFFERENTIAL SCANNING NANOCALORIMETER FOR DIRECT CHARACTIZATION OF BIOMOLECULAR INTERACTIONS

摘要

Disclosed is a differential scanning nanocalorimeter device, methods of fabricating such a device, and methods of use thereof. The nanocalorimeter contains thermal equilibrium areas for sample and reference liquids, with thermometers, compensation heater, and electric trace elements fabricated on a free-standing polymer diaphragm membrane.