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In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
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机译:评估异种生物作为人体肝细胞中药物运输和代谢的免疫调节剂的体外测试系统
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摘要
A method of evaluating the effect of a xenobiotic on biomarkers, such as drug transporters and drug-metabolizing enzymes in hepatocytes is provided. The method comprises the formation of a xenobiotic-stimulated biological sample, such as whole blood, which contains a plurality of cytokines. A portion of xenobiotic-stimulated biological sample is cultured with hepatocytes. The hepatocytes are then analyzed to evaluate the activity of drug transporters and/or drug-metabolizing enzymes, or other biomarkers to determine the effect of the xenobiotic on drug metabolism in the hepatocytes.
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