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Hypoallergenic chimeric proteins belonging to the lipid transfer family of parietaria judaica for use in the treatment of allergies

机译：属于 parietaria judaica 脂质转移家族的低变应原嵌合蛋白，用于治疗过敏

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摘要

The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described. 展开▼

机译：本发明涉及编码DNA的不同变应原的嵌合DNA的重组DNA分子，所述嵌合变种可用于预防和治疗过敏，特别是花粉过敏。具体地，描述了由具有低变应原性特征的变应原Par j 1和Par j 2的片段组成的嵌合多肽。还描述了在异源表达系统中产生这些重组多肽的方法。还描述了纯化嵌合蛋白的有效方法。展开▼

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公开/公告号US8697083B2

专利类型

公开/公告日2014-04-15

原文格式PDF

申请/专利权人 JUAN ANDRES ASTURIAS ORTEGA;ALBERTO MARTINEZ GARATE;ROBERTO GONZALES RIOJA;
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申请/专利号US20070296260

发明设计人 JUAN ANDRES ASTURIAS ORTEGA;ALBERTO MARTINEZ GARATE;ROBERTO GONZALES RIOJA;
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申请日2007-04-11

分类号A61K39;A61K38;A61K39/35;A61K39/36;C12N15/09;C07K1;C07K14;C07K16;C07K17;C08H1;

国家 US

入库时间 2022-08-21 16:03:06

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1. 用于治疗过敏的属于欧蓍草(Parietaria judaica)脂质转移家族的低变应原的嵌合蛋白质 [P] . 中国专利： CN103059140B . 2016.09.28

2. 用于治疗过敏的属于欧蓍草(Parietaria judaica)脂质转移家族的低变应原的嵌合蛋白质 [P] . 中国专利： CN101421296B . 2013.01.02

3. Hypoallergenic chimeric proteins belonging to the lipid transfer family of parietaria judaica for use in the treatment of allergies. [P] . 欧洲知识产权局专利： EP2392592B1 . 2016-12-14

机译：属于犹太教鞭毛虫脂质转移家族的低变应原性嵌合蛋白，用于治疗过敏。

4. Hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in the treatment of allergies [P] . 美国专利： US9522939B2 . 2016-12-20

机译：属于 Parietaria judaica 脂质转移家族的低变应原嵌合蛋白，用于治疗过敏

5. HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT [P] . 日本专利： JP2016104796A . 2016-06-09

机译：犹他氏菌脂质转移家族的低变应原嵌合蛋白，用于过敏性治疗

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11. Supplemental Information 5: Table S2. Cabbage genes encoding proteins with a Pfam domain PF00234 which belong to families other than the non-specific lipid transfer protein family. [O] . -1

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