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Use of Stabilized Granules Containing Glyceryl Trinitrate for Arteriogenesis
Use of Stabilized Granules Containing Glyceryl Trinitrate for Arteriogenesis
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机译:含甘油三硝酸酯的稳定颗粒在动脉生成中的应用
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摘要
The present invention inter alia relates to a method of treating or preventing an arterial insufficiency, wherein an NO donor is administered in an intermitting manner to a subject in an amount effective for the induction of arteriogenesis, and wherein the NO donor is a solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate (GTN), at least one diluent, one carrier material, and at least one substance that reduces the volatility of GTN, whereby this substance is a non-volatile ester stabilizer whose melting point is not higher than 60° C.
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