Stabilized granules containing glyceryl trinitrate to induce arteriogenesis

摘要

A NO donor for use in a method for the prevention or treatment of an arterial insufficiency, wherein the NO donor is administered intermittently in an amount effective for the induction of arteriogenesis, and where the NO donor is trinitrate. of glyceryl in a solid pharmaceutical preparation for oropharyngeal or oral administration characterized in that it contains between 0.05 and 2% by weight of glyceryl trinitrate (GTN), at least one diluent, a carrier material and at least one substance that reduces volatility GTN, so this substance is a non-volatile ester stabilizer whose melting point is not higher than 60 ° C, where the NO donor is administered at least once a day and at least one day a week for at least two weeks.