首页>
外国专利>
Inhibitor scaffold for the inhibition of the enzyme phosphoenolpyruvate carboxykinase
Inhibitor scaffold for the inhibition of the enzyme phosphoenolpyruvate carboxykinase
展开▼
机译:用于抑制磷酸烯醇丙酮酸羧激酶的抑制剂支架
展开▼
页面导航
摘要
著录项
相似文献
摘要
A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent includes a neutral carbon center or include an oxygen, sulfur, selenium, or other atom with similar physiochemical properties; (c) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent is devoid of an electropositive atom or substituents; or (d) a second terminal substituent opposite of the first terminal substituent, said second terminal substituent having an atom that is a hydrogen boding acceptor and/or is negatively charged.
展开▼