首页>
外国专利>
Engineered botulinum neurotoxin C1 with selective substrate specificity
Engineered botulinum neurotoxin C1 with selective substrate specificity
展开▼
机译:工程肉毒杆菌神经毒素C1,具有选择性底物特异性
展开▼
页面导航
摘要
著录项
相似文献
摘要
An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.
展开▼