Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (S1P₂) receptors

摘要

The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist biological activity, wherein these compounds selected from the group consisting of; wherein A, B, C, D, X, Y, Z and R³ are defined in the specification. Said compounds are useful for treating a disease or condition of a mammal selected from the group consisting of ocular diseases; systemic vascular barrier related diseases; allergies and other inflammatory diseases; cardiac diseases or conditions; fibrosis; pain and wounds.