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Metronidazole resistance in trichomonas vaginalis and single nucleotide polymorphisms

机译：阴道滴虫的甲硝唑耐药性和单核苷酸多态性

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摘要

The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant Trichomonas vaginalis. The presence of G76C, C213G, or C318A (SNP) in tvntr 4 or the presence of A238T, G427C, or T476C (SNP) in tvntr6 provides a reliable biomarker for the presence of metronidazole-resistant Trichomonas vaginalis. The present invention further provides reagents used for detecting the SNPs to screen subjects for metronidazole resistance in Trichomonas vaginalis.

机译：本发明针对在存在甲硝唑抗性的阴道毛滴虫的情况下发现单核苷酸多态性（SNP）。 tvntr 4中G76C，C213G或C318A（SNP）的存在或tvntr6中A238T，G427C或T476C（SNP）的存在为耐甲硝唑的阴道毛滴虫的存在提供了可靠的生物标记。。本发明进一步提供了用于检测SNP以筛选受试者阴道滴虫中甲硝唑抗性的试剂。 展开▼

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公开/公告号US8741563B2

专利类型

公开/公告日2014-06-03

原文格式PDF

申请/专利权人 MEDICAL DIAGNOSTIC LABORATORIES LLC;
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申请/专利号US201213680553

发明设计人 TERESA PAULISH-MILLER;DAVID W. HILBERT;SCOTT E. GYGAX;MARTIN E. ADELSON;ELI MORDECHAI;JESSICA SCHUYLER;
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申请日2012-11-19

分类号C12Q1/68;C12P19/34;C12P31/00;C07H21/04;

国家 US

入库时间 2022-08-21 16:01:32

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