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METRONIDAZOLE RESISTANCE IN TRICHOMONAS VAGINALIS AND SINGLE NUCLEOTIDE POLYMORPHISMS

机译：阴道毛滴虫和单核苷酸多态性对甲硝唑的耐药性

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摘要

The present invention is directed to the discovery of single nucleotide polymorphisms (SNPs) in the presence of metronidazole-resistant Trichomonas vaginalis. The presence of G76C, C213G, or C318A (SNP) in tvntr 4 or the presence of A238T, G427C, or T476C (SNP) in tvntr6 provides a reliable biomarker for the presence of metronidazole-resistant Trichomonas vaginalis. The present invention further provides reagents used for detecting the SNPs to screen subjects for metronidazole resistance in Trichomonas vaginalis.

机译：本发明针对在存在甲硝唑抗性阴道毛滴虫的情况下发现单核苷酸多态性（SNP）。 tvntr 4中存在G76C，C213G或C318A（SNP）或tvntr6中存在A238T，G427C或T476C（SNP）为存在耐甲硝唑的阴道毛滴虫提供了可靠的生物标记。本发明进一步提供了用于检测SNP的试剂，以筛选受试者阴道滴虫中的甲硝唑抗性。 展开▼

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公开/公告号US2013130253A1

专利类型

公开/公告日2013-05-23

原文格式PDF

申请/专利权人 MEDICAL DIAGNOSTIC LABORATORIES LLC;
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申请/专利号US201213680553

发明设计人 TERESA PAULISH-MILLER;DAVID W. HILBERT;SCOTT E. GYGAX;MARTIN E. ADELSON;ELI MORDECHAI;JESSICA SCHUYLER;
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申请日2012-11-19

分类号C12Q1/68;

国家 US

入库时间 2022-08-21 16:49:51

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