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Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity
Real-time, single-step bioassay using nanoplasmonic resonator with ultra-high sensitivity
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机译:使用超高灵敏度的纳米等离子体共振器进行实时,一步生物测定
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摘要
A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.
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