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DNA vaccination for treatment of multiple sclerosis and insulin-dependent diabetes mellitus
DNA vaccination for treatment of multiple sclerosis and insulin-dependent diabetes mellitus
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机译:DNA疫苗接种治疗多发性硬化症和胰岛素依赖型糖尿病
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摘要
A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-γ and IL-15, are reduced.
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