首页>
外国专利>
Knockin mouse with a disruption in a PXR gene expressing human PXR
Knockin mouse with a disruption in a PXR gene expressing human PXR
展开▼
机译:敲除表达人PXR的PXR基因的小鼠
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to transgenic non-human animals, tissues or cells derived therefrom and methods of producing them. The transgenic non-human animals or tissues or cells derived therefrom provide a system capable of expressing human proteins responsible for drug metabolism in place of the homologous endogenous non-human animal proteins and for the controlled expression of human genes introduced into the animal so that the expression of the human genes is regulated in a manner more closely analogous to that seen in vivo in humans. One aspect of the invention relates to the use of a human DNA sequence comprising at least part of introns 6 and/or 7 of the human PXR gene.
展开▼