Process for the preparation of Crystalline forms and their polymorphs of agomelatine

摘要

Procedure for the preparation of Crystalline forms of agomelatine and their polymorphs. Procedure for the preparation of two Crystalline forms of agomelatine, in particular a preparation Procedure of the form I and form of agomelatine, here called form VII.Claim 1: procedure for the preparation of Crystalline forms of agomelatine, which comprises the preparation of the form I and form VII of agomelatine, from a solution in a Solvent of agomelatine characterized by Crystallizing agomelatine by precipitation The snapshot from the solution to a temperature equal to or below - 10C.Taking the Solvent Freezing Point lower than this temperature. Claim 10: polymorphs, as claimed in 9, characterized by the form of agomelatine Crystal form VII and which has the following significant Peaks: Angle 2 - Q 9.48, 10.30, 11.84, 13,16, 15, 17, 24, 16.08, 19.06, 20,30, 21.14, 23,84, 25.70, 28.47, 30.5.