A Molecule of anti B Antibody A4 / AB4, a preparation method thereof and a method for its Optimization, a Molecule of nucleic acid, vector, host Cell, uses, a Pharmaceutical composition, a Composition of diagnosis, a Kit and a method for preparing a Pharmaceutical composition

摘要

A specific antibody molecule of b-a4 / ab4 peptide, wherein the first region includes the aefrhdsgy amino acid sequence as shown in the seqd1 file or a part thereof, and the second region includes the vhqklvffaedvg amino acid sequence as shown in seqd1. Ibid., No. 2 or part thereof, wherein the antibody molecule includes: (a) a variable VL region, including complementary decision regions l-cdr1, l-cdr2 and l-cdr3, wherein: (1) l-cdr1 consists of classifications 96, 130-133, 141-143, 160 and 175-177.180, 189, 190, 200, 201, 206-211 and 224; (2) l-cdr2 selects a sequence from groups 97, 144, 161 and 212 of SEQ ID; l-cdr3 selects a sequence from groups 16, 18, 20, 75, 77, 79, 81, 83, 85, 87, 95, 98, 102, 103-107, 145, 149-159, 162 and 166 of SEQ ID, Paragraphs 178, 183, 202, 213, 217, 218, 220, 385, 387, 389, 391, 393, 395, 397, 399, 401, 403, 405, 407, 409, 411, and 413; and (b) a variable VH region, including complementary decision regions h-cdr1, h-cdr2, and h-cdr3, wherein: (1) the Commission on human rights selects a sequence from paragraphs 99, 146, 163 of SEQ ID.(2) H-cdr2 selects a group of people from SEQ No. 100, 108-129, 134-140, 147, 164, 167-174, 179, 181, 182, 184-188, 191-199, 204, 205, 215, 219 and 221-223; and (3) h-cdr3 selects a group of people from SEQ No. 22, 24, 26, 61, 63 and 65. Ibid., Paras. 67, 69, 71, 73, 93, 101, 148, 165, 216, 355, 357, 359, 361, 363, 365, 367, 369, 371, 373, 375, 377, 379, 381 and 383. In addition, a preparation method, an optimization method and a nucleic acid molecule are provided for encoding antibody molecules.a. Carrier and host cell, including nucleic acid molecule; use of antibody molecule, nucleic acid molecule, carrier or host cell; drug composition of antibody molecule; A diagnostic component including an antibody molecule; a tool kit; and a preparation method of a pharmaceutical component.