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Procedure for the formulation of a vaccine that contains at least two antigens can be Adsorbed onto the Oxy hydroxide Aluminium
Procedure for the formulation of a vaccine that contains at least two antigens can be Adsorbed onto the Oxy hydroxide Aluminium
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机译:可以将至少包含两种抗原的疫苗的制备过程吸附到氢氧化氧铝上
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摘要
A procedure for preparing a vaccine composition comprising at least Oxy hydroxide Aluminum (aiooh), and at least the hepatitis B surface antigen and Antigen of Haemophilus influenzae type B in accordance with this, the hepatitis B surface antigen is Man Is adsorbed on the aiooh while the Hib Antigen remains adsorbed.To this effect: proceeds to adsorb the hepatitis B surface antigen on aiooh to obtain a complex aiooh / HBsAg, then mixing the complex aiooh / HBsAg with Hib Antigen in the presence of cationic amino acid at a concentration of 100 mg / l, and Ion fo Sfato at a concentration of 35 to 45 mmol / 1.Claim 7: a method according to claim 1, characterized in that it consists in: preparing a composition comprising at least one Antigen selected among the antigens of Diphtheria, Tetanus, polio, whooping cough, as well as the Oxy Hydroxy Aluminum, and mix the complex aiooh / HBsAg with said compositionPrior to mixing with the Hib Antigen.
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